Which body system is primarily affected by excessive fluoride exposure?

Excessive fluoride exposure primarily affects the skeletal system. High levels of fluoride can lead to a condition known as skeletal fluorosis, which is characterized by the accumulation of fluoride in bones. This accumulation can cause changes in bone structure and density, leading to symptoms such as pain, stiffness, and increased risk of fractures. In severe cases, it can result in deformities and calcification of ligaments, severely impacting mobility and overall skeletal health.

While fluoride can have effects on other body systems, such as the nervous and digestive systems, its most well-documented and significant impact is on the skeletal system. This makes it crucial for individuals to be aware of fluoride levels in their environment, especially in areas where water is fluoridated or where industrial exposure might occur.